Slither Inc.'s head office

Slither HQ is the headquarters of Slither Inc., and also the largest building construction in Mega Man ZX, accessed from Area D-2 after obtaining all Biometals. It has a lotus-like structure on top releasing energy and is protected by four giant walls.

The building collapsed after Serpent's defeat in the end of Mega Man ZX. After Mega Man ZX, its remains were repurposed as an energy Control Center, which years later would be attacked by Queenbee in Mega Man ZX Advent to retrieve Serpent's Model W fragment.

Enemies

 * Carom
 * Cutting Gyro
 * Energy Cannon
 * Galleon Burner
 * Galleon Hunter
 * Platform Cannon
 * Whirling 38
 * Whirling 44
 * Boss: Rematches against the eight Pseudoroids
 * Boss: Serpent (1st form)
 * Boss: Serpent (2nd form)